diff --git a/eng/pipelines/templates/stages/archetype-python-release.yml b/eng/pipelines/templates/stages/archetype-python-release.yml
index 4cf30f556912..67adf746a17a 100644
--- a/eng/pipelines/templates/stages/archetype-python-release.yml
+++ b/eng/pipelines/templates/stages/archetype-python-release.yml
@@ -280,6 +280,10 @@ stages:
                   inputs:
                     versionSpec: '3.11'
 
+                - pwsh: |
+                    Write-Host "##vso[task.setvariable variable=PIP_NO_BUILD_ISOLATION]1"
+                  displayName: 'Set PIP_NO_BUILD_ISOLATION=1 for py2docfx'
+
                 - template: /eng/pipelines/templates/steps/install-rex-validation-tool.yml
 
                 - template: /eng/common/pipelines/templates/steps/update-docsms-metadata.yml
diff --git a/eng/scripts/docs/py2docfx_requirements.txt b/eng/scripts/docs/py2docfx_requirements.txt
index fd2c0a2051f7..a0481f76cebb 100644
--- a/eng/scripts/docs/py2docfx_requirements.txt
+++ b/eng/scripts/docs/py2docfx_requirements.txt
@@ -1 +1,3 @@
 py2docfx==0.1.24
+setuptools==77.0.3
+wheel==0.45.1