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1148 lines (815 loc) · 35.1 KB
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<!DOCTYPE HTML>
<html>
<head>
<meta charset="utf-8">
<title>Ion-Channel-Classification </title>
<script src="https://d3js.org/d3.v6.min.js"></script>
<style>
.node circle {
fill: steelblue;
stroke: steelblue;
stroke-width: 1.5px;
}
.node {
font: 11px sans-serif;
font-weight: bold;
}
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fill: none;
stroke: #bbb;
stroke-width: 1.5px;
}
</style>
</head>
<body>
<script type="text/javascript">
var width = 1100,
height = 3500;
var cluster = d3.layout.cluster()
.size([height, width - 620]);
var diagonal = d3.svg.diagonal()
.projection(function (d) {
return [d.y, d.x];
});
var svg = d3.select("body").append("svg")
.attr("width", width)
.attr("height", height)
.append("g")
.attr("transform", "translate(115,0)");
var root = getData(),
nodes = cluster.nodes(root),
links = cluster.links(nodes);
var link = svg.selectAll(".link")
.data(links)
.enter()
.append("path")
.attr("class", "link_continuous")
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.style("stroke", function(d) { return d.target.level; });
var node = svg.selectAll(".node")
.data(nodes)
.enter()
.append("g")
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.attr("transform", function (d) {
return "translate(" + d.y + "," + d.x + ")";
})
node.append("circle")
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node.append("text")
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.text(function (d) { return d.name; });
d3.select(self.frameElement).style("height", height + "px");
function getData() {
return {
"name": "CRC",
"children": [{
//calcium channels-----------------------------------------
"name":"Calcium ion channels",
"level": "red",
"children": [
{
"name": "Ca voltage-gated subunits",
"level": "red",
"children": [
{
"name": "Ca voltage gated channel alpha 1 subuinits",
"children": [{"name" : "Ca voltage-gated channel subunit alpha1 C (Q13936)"},
{"name" : "Ca voltage-gated channel subunit alpha1 H (O95180)"},
{"name" : "Ca voltage-gated channel subunit alpha1 G (O43497)"},
{"name" : "Ca voltage-gated channel subunit alpha1 A (O00555)"},
{"name" : "Ca voltage-gated channel subunit alpha1 D (Q01668)"},
{"name" : "Ca voltage-gated channel subunit alpha1 C (E9PDI6)"},
{"name" : "Ca voltage-gated channel subunit alpha1 C (F5H522)"},
{"name" : "Ca voltage-gated channel subunit alpha1 C (A0A0A0MSA1)"},
{"name" : "Ca voltage-gated channel subunit alpha1 C (F5H638)"},
{"name" : "Ca voltage-gated channel subunit alpha1 C (F5GY28)"},
{"name" : "Ca voltage-gated channel subunit alpha1 C (A0A0A0MR67)"}]
},
{
"name": "Ca channel auxiliary gamma subunits",
"children": [{"name" : "Ca voltage-gated channel auxiliary subunit gamma 7 (P62955)"},
{"name" : "Ca voltage-gated channel auxiliary subunit gamma 8 (Q8WXS5)"},
{"name" : "Ca voltage-gated channel auxiliary subunit gamma 4 (Q9UBN1)"},
{"name" : "Ca voltage-gated channel auxiliary subunit gamma 6 (Q9BXT2)"}]
},
{
"name": "Ca voltage-gated channel auxiliary beta subunits",
"children": [{"name" : "Ca voltage-gated channel auxiliary subunit beta 2 (Q08289)"},
{"name" : "Ca voltage-gated channel auxiliary subunit beta 1 (Q02641)"},
{"name" : "Ca voltage-gated channel auxiliary subunit beta 2 (A0A087WVX5)"},
{"name" : "Ca channel voltage-dependent subunit beta 1 (Q6TME4)"},
{"name" : "Ca channel voltage-dependent subunit beta 2 (Q5VVH1)"},
{"name" : "Ca channel voltage-dependent subunit beta 2 (Q6TME0)"}]
},
{
"name": "Ca voltage-gated channel auxiliary subunit alpha2delta subunits",
"level": "red",
"children":[{"name" : "Ca voltage-gated channel auxiliary subunit alpha2delta 1 (P54289)"},
{"name" : "Ca voltage-gated channel auxiliary subunit alpha2delta 2 (Q9NY47) (mito)","level": "red"}]
}
],
},
{
"name": "Ryanodine receptors",
"level": "red",
"children": [
{"name": "ryanodine receptor 1 (P21817) (mito)","level": "red"},
{"name": "ryanodine receptor 2 (Q92736) (mito)","level": "red"},
{"name": "ryanodine receptor 2 (H7BY35)"},
{"name": "ryanodine receptor (B4DWD0) (mito)","level": "red"}]
},
{
"name": "Two pore segment channels",
"children": [
{"name": "two pore segment channel 1 (Q9ULQ1)"}
]
}
]},
//potasium channels----------------------------------------------------------------
{
"name":"Potassium channels",
"children":
[
{
"name": "K-Ca activated channels",
"children": [
{"name": "K-Ca activated channel subfamily M alpha 1 (Q12791)"},
{"name": "K-Ca activated channel subfamily M regulatory beta subunits",
"children": [{"name" : "K-Ca activated channel subfamily M regulatory beta subunit 3 (Q9NPA1)"},
{"name" : "K-Ca activated channel subfamily M regulatory beta subunit 2 (Q9Y691)"}]
}
]
},
{
"name": "K voltage-gated channel regulatory subunits",
"children": [
{"name" : "K voltage-gated channel interacting protein 2 (Q9NS61)"},
{"name" : "K voltage-gated channel subfamily A member 5 (P22460)"},
{"name" : "K voltage-gated channel subfamily B member 1 (Q14721)"},
{"name":"Kv channel interacting protein 2 transcript variant 9 (Q09MK0)"}
]
},
{
"name": "K two pore domain channel subfamily K",
"children": [{"name": "K two pore domain channel subfamily K member 3 (O14649)"}]
},
],
},
//sodium channel---------------------------------------------------------------
{
"name":"Na channels",
"children": [
{
"name": "Na voltage-gated channel alpha subunits",
"children": [
{"name": "Na voltage-gated channel alpha subunit 5 (Q14524)"},
]
}
],
},
//cloride channels----------------------------------------------------------
{
"name":"Cloride channels",
"children": [
{
"name": "Ca activated Cl channel subunits",
"children": [
{"name": "tweety family member 3 (Q9C0H2)"},
{"name": "tweety family member 2 (Q9BSA4)"}
]
},
{
"name": "Chloride intracellular channels",
"children": [
{"name": "chloride intracellular channel 4 (Q9Y696)"},
{"name": "chloride intracellular channel 2 (O15247)"}
]
}
],
},
//Nonselective channels---------------------------
{
"name":"Nonselective channels",
"level": "red",
"children":
[
{
"name": "Transient receptor potential cation channels",
"children": [
{"name": "transient receptor potential cation channel subfamily M member 4 (Q8TD43)"},
{"name": "transient receptor potential cation channel subfamily M member 2 (O94759) (mito)","level": "red"},
{"name": "transient receptor potential cation channel subfamily M member 4 (Q9UBN4)"},
{"name": "Polycystic kidney disease protein 1-like 1 (Q8TDX9)"},
{"name": "polycystin 2, transient receptor potential cation channel(Q13563)"},
{"name": "polycystin 1 like 3, transient receptor potential channel interacting(Q7Z443)"},
{"name": "polycystin 2 like 1, transient receptor potential cation channel(Q9P0L9)"},
{"name": "Polycystic kidney disease protein 1-like 2(Q7Z442)"},
{"name": "Polycystin-1(P98161)"},
{"name": "Short transient receptor potential channel 4(Q9UBN4)"}
]
},
],
},
// ATPases Ca transporting----------------------------------
{
"name":"ATPases Ca transporting",
"level": "red",
"children":
[
{"name": "ATPase sarcoplasmic/endoplasmic reticulum Ca transporting 2 (P16615) (mito)","level": "red"},
{"name": "ATPase plasma membrane Ca transporting 4 (P23634)"},
],
},
//Calcium sensing receptors----------------------------------
{
"name":"Ca sensing receptors",
"children":
[
{"name": "Ca sensing receptor (P41180)"}
],
},
//Actinins----------------------------------
{
"name":"Actins",
"children":
[
{"name": "actinin alpha 1 (P12814)"},
{"name": "actinin alpha 2 (P35609)"},
],
},
//Inositol 1,4,5-triphosphate receptors----------------------------------
{
"name":"Inositol 1,4,5-triphosphate receptors",
"level": "red",
"children": [
{
"name": "inositol 1,4,5-trisphosphate receptor type 1 (Q14643) (mito)","level": "red"
},
{
"name": "inositol 1,4,5-trisphosphate receptor type 2 (Q14571) (mito)","level": "red"
},
{
"name": "inositol 1,4,5-trisphosphate receptor type 3 (Q14573) (mito)","level": "red"
},
],
},
//Solute carriers----------------------------------
{
"name":"Solute carriers",
"level": "red",
"children":
[
{"name": "Sodium/potassium/calcium exchanger 1 (O60721)"},
{"name": "Sodium/calcium exchanger 1 (P32418)"},
{"name": "Sodium/hydrogen exchanger 1 (P19634)"},
{"name": "Mitochondrial sodium/calcium exchanger protein (Q6J4K2) (mito)","level": "red"},
{"name": "solute carrier family 11 member 2 (P49281) (mito)","level": "red"}
],
},
//PDZ domain containing----------------------------------
{
"name":"PDZ domain containing",
"children": [
{
"name": "Na/H exchange regulatory cofactor NHE-RF4 (Q86UT5)",
},
{
"name": "syntrophin alpha 1 (Q13424)",
},
{
"name": "syntrophin beta 2 (Q13425)",
},
{
"name": "nitric oxide synthase 1 (P29475)",
},
],
},
//Gap junction Proteins----------------------------------
{
"name":"Gap junction Proteins",
"children": [
{
"name": "gap junction protein alpha 1 (P17302)",
},
{
"name": "gap junction protein alpha 1 (A0A654IBU3)",
},
{
"name": "gap junction protein alpha 4 (P35212)",
},
],
},
//Cardiac phospholamban----------------------------------
{
"name":"Cardiac phospholamban (Q5R352)",
},
{
"name":"Cardiac phospholamban (P26678)",
},
//Triadin----------------------------------
{
"name":"Triadin (Q13061)",
},
//Serine/threonine-protein kinase WNK3----------------------------------
{
"name":"Serine/threonine-protein kinase WNK3 (Q9BYP7)",
},
//Receptor ligands----------------------------------
{
"name":"Receptor ligands",
"children": [
{
"name": "calmodulin 1 (P0DP23)",
},
{
"name": "calmodulin 2 (P0DP24)",
},
{
"name": "calmodulin 3 (P0DP25)",
},
{
"name": "amyloid beta precursor protein (P05067)",
},
],
},
//Receptor ligands----------------------------------
{
"name":"Receptor ligands",
"children": [
{
"name": "calmodulin 1 (P0DP23)",
},
{
"name": "calmodulin 2 (P0DP24)",
},
{
"name": "calmodulin 3 (P0DP25)",
},
{
"name": "amyloid beta precursor protein (P05067)",
},
],
},
//Purinergic receptors P2X----------------------------------
{
"name":"Purinergic receptors P2X",
"children": [
{
"name": "purinergic receptor P2X 3 (P56373)",
},
],
},
//Calmodulin dependent protein kinases----------------------------------
{
"name":"Calmodulin dependent protein kinases",
"children": [
{
"name": "calcium/calmodulin dependent protein kinase II delta(Q13557)",
},
],
},
//Galanin receptors----------------------------------
{
"name":"Galanin receptors",
"children": [
{
"name": "Galanin receptor type 2 (O43603)",
},
],
},
//Protein phosphatase catalytic subunits----------------------------------
{
"name":"Protein phosphatase catalytic subunits",
"children": [
{
"name": "protein phosphatase 3 catalytic subunit alpha ",
"children": [
{
"name": "Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (Q08209) (mito)","level": "red"
}
]
},
],
},
//Syntaxins----------------------------------
{
"name":"Syntaxins",
"children": [
{
"name": "syntaxin 1A (Q16623) ",
},
],
},
//EF hand domain containing----------------------------------
{
"name":"EF hand domain containing",
"children": [
{
"name": "sorcin (P30626)",
},
{
"name": "selenoprotein N (Q9NZV5)",
},
{
"name": "Calcineurin B homologous protein 1 (Q99653)",
},
{
"name": "calcium and integrin binding 1 (Q99828)",
},
{
"name": "EH domain containing 3 (Q9NZN3)",
},
{
"name": "mitochondrial calcium uptake 1 (Q9BPX6)",
},
{
"name": "mitochondrial calcium uptake 2 (Q8IYU8) (mito)","level": "red"
}
],
},
//SH2 domain containing---------------------------------
{
"name":"SH2 domain containing",
"children": [
{
"name": "Tyrosine-protein kinase Fyn (P06241)",
},
],
},
//Phosphodiesterases---------------------------------
{
"name":"Phosphodiesterases",
"children": [
{
"name": "phosphodiesterase 4D (Q08499)",
},
],
},
//Proprotein convertase subtilisin/kexin family---------------------------------
{
"name":"Proprotein convertase subtilisin/kexin family",
"children": [
{
"name": "proprotein convertase subtilisin/kexin type 9 (Q8NBP7)",
},
],
},
//Troponin complex subunits---------------------------------
{
"name":"Troponin complex subunits",
"children": [
{
"name": "troponin I3 (P19429)",
},
],
},
//Integrin beta subunits---------------------------------
{
"name":"Integrin beta subunits",
"children": [
{
"name": "integrin subunit beta 1 (P05556)",
},
],
},
//Wnt family---------------------------------
{
"name":"Wnt family",
"children": [
{
"name": "Wnt family member 3A (P56704)",
},
],
},
//Soluble glutathione S-transferases---------------------------------
{
"name":"Soluble glutathione S-transferases",
"children": [
{
"name": "glutathione S-transferase omega 1 (P78417)",
},
],
},
//presenilin---------------------------------
{
"name":"presenilin",
"children": [
{
"name": "presenilin 1 (P49768)",
},
],
},
//Phosphofurin acidic cluster sorting protein 2--------------------------------
{
"name":"Phosphofurin acidic cluster sorting protein 2",
"children": [
{
"name": "phosphofurin acidic cluster sorting protein 2 (Q86VP3)",
},
],
},
//F-BAR domain containing-------------------------------
{
"name":"F-BAR domain containing",
"children": [
{
"name": "protein kinase C and casein kinase substrate in neurons 3 (Q9UKS6)",
},
],
},
//N-BAR domain containing-------------------------------
{
"name":"N-BAR domain containing",
"children": [
{
"name": "bridging integrator 1 (O00499)",
},
],
},
//Bridging integrator 1, isoform CRA_k-------------------------------
{
"name":"Bridging integrator 1, isoform CRA_k (A0A024RAF1)",
},
//Serum paraoxonase/arylesterase 1-------------------------------
{
"name":"Serum paraoxonase/arylesterase 1",
"children": [
{
"name": "paraoxonase 1 (P27169)",
},
],
},
//histidine rich calcium binding protein-------------------------------
{
"name":"histidine rich calcium binding protein",
"children": [
{
"name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein (P23327)",
},
],
},
//histidine rich calcium binding protein-------------------------------
{
"name":"histidine rich calcium binding protein",
"children": [
{
"name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein (P23327)",
},
],
},
//Neuropeptides-------------------------------
{
"name":"Neuropeptides",
"children": [
{
"name": "natriuretic peptide A (P01160)",
},
],
},
//BCL2 family-------------------------------
{
"name":"BCL2 family",
"children": [
{
"name": "BCL2 antagonist/killer 1 (Q16611)",
},
],
},
//Formins-------------------------------
{
"name":"Formins",
"children": [
{
"name": "diaphanous related formin 1 (O60610)",
},
],
},
//FKBP prolyl isomerases-------------------------------
{
"name":"FKBP prolyl isomerases",
"children": [
{
"name": "Peptidyl-prolyl cis-trans isomerase FKBP1A (P62942)",
},
{
"name": "FKBP prolyl isomerase 1B (P68106)",
},
{
"name": "FKBP prolyl isomerase 4 (Q02790)",
}
]
},
//AGC family kinases-------------------------------
{
"name":"AGC family kinases",
"children": [
{
"name": "protein kinase cAMP-activated catalytic subunit alpha (P17612)",
},
{
"name": "protein kinase C alpha (P17252)",
}
]
},
//14-3-3 phospho-serine/phospho-threonine binding proteins-------------------------------
{
"name":"14-3-3 phospho-serine/phospho-threonine binding proteins",
"children": [
{
"name": "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (P62258) (mito)","level": "red"
}
]
},
//MicroRNA protein coding host genes-------------------------------
{
"name":"MicroRNA protein coding host genes",
"children": [
{
"name": "nitric oxide synthase 1 adaptor protein (O75052)",
}
]
},
//Dystrophin-------------------------------
{
"name":"Dystrophin (P11532)",
},
{
"name":"Dystrophin (A0A075B6G3)",
},
//aspartate beta-hydroxylase-------------------------------
{
"name":"aspartate beta-hydroxylase (Q12797)",
},
//Caveolins-------------------------------
{
"name":"Caveolins",
"children": [
{
"name": "caveolin 1 (Q03135)",
},
{
"name": "caveolin 3 (P56539)",
},
]
},
//Protein disulfide isomerases------------------------------
{
"name":"Protein disulfide isomerases",
"children": [
{
"name": "calsequestrin 2 (O14958)",
},
]
},
//A-kinase anchoring proteins------------------------------
{
"name":"A-kinase anchoring proteins",
"children": [
{
"name": "A-kinase anchoring protein 6 (Q13023)",
},
]
},
//Heat shock 70kDa proteins------------------------------
{
"name":"Heat shock 70kDa proteins",
"children": [
{
"name": "heat shock protein family A (Hsp70) member 5 (P11021)",
},
]
},
//Annexins------------------------------
{
"name":"Annexins",
"children": [
{
"name": "annexin A7 (P20073)",
},
]
},
//Neurexins-----------------------------
{
"name":"Neurexins",
"children": [
{
"name": "neurexin 1 (P58400)",
},
]
},
//Junctophilins-----------------------------
{
"name":"Junctophilins",
"children": [
{
"name": "junctophilin 1 (Q9HDC5)",
},
{
"name": "junctophilin 2 (Q9BR39)",
}
]
},